منابع مشابه
The fic domain: regulation of cell signaling by adenylylation.
We show that the secreted antigen, IbpA, of the respiratory pathogen Histophilus somni induces cytotoxicity in mammalian cells via its Fic domains. Fic domains are defined by a core HPFxxGNGR motif and are conserved from bacteria to humans. We demonstrate that the Fic domains of IbpA catalyze a unique reversible adenylylation event that uses ATP to add an adenosine monophosphate (AMP) moiety to...
متن کاملStructure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain.
The FIC motif and the eukaryotic-like ankyrin repeats are found in many bacterial type IV effectors, yet little is known about how these domains enable bacteria to modulate host cell functions. Bacterial FIC domains typically bind ATP and transfer adenosine monophosphate moiety onto target proteins. The ankyrin repeat-containing protein AnkX encoded by the intracellular pathogen Legionella pneu...
متن کاملKinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.
The bacterial pathogen Vibrio parahemeolyticus manipulates host signaling pathways during infections by injecting type III effectors into the cytoplasm of the target cell. One of these effectors, VopS, blocks actin assembly by AMPylation of a conserved threonine residue in the switch 1 region of Rho GTPases. The modified GTPases are no longer able to interact with downstream effectors due to st...
متن کاملCrystal Structure of the Human, FIC-Domain Containing Protein HYPE and Implications for Its Functions
Protein AMPylation, the transfer of AMP from ATP to protein targets, has been recognized as a new mechanism of host-cell disruption by some bacterial effectors that typically contain a FIC-domain. Eukaryotic genomes also encode one FIC-domain protein,HYPE, which has remained poorly characterized.Here we describe the structure of human HYPE, solved by X-ray crystallography, representing the firs...
متن کاملSpeeding-Up Color FIC Using
In this paper, speeding-up fractal color image compression technique based on zero-mean method by adding symmetry predictor to reduce the number of isometric trails from 8 to one trail. The first order centralized moments are used to index each domain and range blocks onto one of eight possible isometric states. At each range domain the indices of both domain and range blocks are passed through...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2009
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2696